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the more advanced condition is called chronic venous insufficiency (Eberhardt 2014
Oxidative stress in liver injury ROS include the free radicals superoxide (O 2 - ) and hydroxyl radical (HO - ) and non-radicals such as hydrogen peroxide (H 2 O 2 )
Supportive secondary end points were not included in the statistical testing hierarchy and, as such, not controlled for multiplicity
While there is no direct pharmacokinetic interaction between tirzepatide and anticoagulants listed in the SmPC, indirect effects warrant consideration
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